منابع مشابه
Differential social regulation of two pituitary gonadotropin-releasing hormone receptors.
In many vertebrates, social interactions regulate reproductive capacity by altering the activity of the hypothalamic-pituitary-gonadal (HPG) axis. To better understand the mechanisms underlying social regulation of reproduction, we investigated the relationship between social status and one main component of the HPG axis: expression levels of gonadotropin-releasing hormone receptor (GnRH-R). So...
متن کاملGonadotropin-releasing hormone receptors: where did they come from?
Pope got it right, although amphioxus is a slimy ancestor to acknowledge. But what does this beast have to tell us about our origins? In this issue, Tello and Sherwood (1) propose that in amphioxus, the most basal chordate, four GnRH receptors are present: two that sit at the base of the invertebrate lineage and two at the base of the vertebrate lineage. Amphioxus, also known as the lancelet, g...
متن کاملAgonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors
Gonadotropin-releasing hormone (GnRH) acts via seven transmembrane receptors to stimulate gonadotropin secretion. Sustained stimulation desensitizes GnRH receptor (GnRHR)-mediated gonadotropin secretion, and this underlies agonist use in hormone-dependent cancers. Since type I mammalian GnRHR do not desensitize, agonist-induced internalization and downregulation may underlie desensitization of ...
متن کاملRegulation of pituitary gonadotropin-releasing hormone receptors by pulsatile gonadotropin-releasing hormone injections in male rats. Modulation by testosterone.
The pattern of the gonadotropin-releasing hormone (GnRH) stimulus is critically important in the regulation of pituitary gonadotropin secretion and continuous infusions down-regulate secretion while intermittent pulses maintain luteinizing hormone (LH) and follicle-stimulating hormone (FSH) responsiveness. We examined the effects of pulsatile GnRH administration on pituitary GnRH receptors (GnR...
متن کاملPulsatile administration of gonadotropin-releasing hormone agonist to gilts actively immunized against gonadotropin-releasing hormone.
Sexually mature gilts (n = 20) were actively immunized against GnRH. Primary and booster immunizations of GnRH conjugated to bovine serum albumin induced production of antibodies in all gilts. Nineteen of the gilts became acyclic with suppressed concentrations of gonadotropins and estradiol. Intravenous challenges with 100 micrograms GnRH and 5 micrograms D-(Ala6, des-Gly-NH2(10)) ethylamide Gn...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2004
ISSN: 0163-769X,1945-7189
DOI: 10.1210/er.2003-0002